Iziguli ze-Chronic kidney disease (CKD) zivame ukuba ne-hyperphosphatemia, kanti i-hyperphosphatemia yesikhathi eside ingaholela ezinkingeni ezinkulu njenge-hyperparathyroidism yesibili, i-renal osteodystrophy, nesifo senhliziyo. Ukulawula amazinga e-phosphorus egazini kuyingxenye ebalulekile yokuphathwa kweziguli ezine-CKD, futhi ama-phosphate binder ayimithi eyisisekelo yokwelapha i-hyperphosphatemia. Eminyakeni yakamuva,i-lanthanum carbonate, njengohlobo olusha lwe-non-calcium ne-non-aluminium phosphate binder, liye langena kancane kancane emkhakheni wombono wabantu futhi laqala "ukuncintisana" nezibophezelo ze-phosphate zendabuko.
"Izimfanelo" kanye "nobubi" bezibophezelo ze-phosphate zendabuko
Izibophezelo ze-phosphate zendabuko ikakhulukazi zihlanganisa izibophezelo ze-phosphate ezine-calcium (ezifana ne-calcium carbonate ne-calcium acetate) nezibophezelo ze-phosphate ezine-aluminium (njenge-aluminium hydroxide). Ahlangana nama-phosphates ekudleni ukuze enze izinhlanganisela ezingancibiliki, ngaleyo ndlela anciphise ukumuncwa kwe-phosphorus emathunjini.
Izibophezelo ze-phosphate ezine-calcium: Intengo ephansi kanye nomphumela oqondile wokunciphisa i-phosphorus, kodwa ukusetshenziswa kwesikhathi eside kungaholela ku-hypercalcemia futhi kwandise ingozi yokubala kwemithambo.
Izibophezelo ze-phosphorus ezine-aluminium: Umphumela onamandla wokunciphisa i-phosphorus, kodwa ukunqwabelana kwe-aluminium kunobuthi obukhulu futhi kungabangela isifo samathambo esihlobene ne-aluminium kanye ne-encephalopathy, futhi okwamanje asetshenziswa kancane.
I-Lanthanum carbonate: Ukukhuphuka okusha, okunezinzuzo ezivelele
I-Lanthanum carbonate iyi-carbonate ye-rare earth metal element lanthanum, enomshini oyingqayizivele wokubopha i-phosphorus. Ikhulula ama-ion e-lanthanum endaweni ene-acidic ye-digestive tract futhi yakhe i-lanthanum phosphate engancibiliki kakhulu ne-phosphate, ngaleyo ndlela ivimbele ukumuncwa kwe-phosphorus.
Isingeniso esifushane se-lanthanum carbonate
| Igama lomkhiqizo | I-Lanthanum carbonate |
| Ifomula | I-La2(CO3)3.xH2O |
| Inombolo ye-CAS. | 6487-39-4 |
| Isisindo samangqamuzana | 457.85 (anhy) |
| Ukuminyana | 2.6 g/cm3 |
| Iphoyinti lokuncibilika | N/A |
| Ukubukeka | I-crystal powder emhlophe |
| Ukuncibilika | Incibilika emanzini, incibilika ngokulingene kuma-acid amaminerali aqinile |
| Ukuzinza | I-hygroscopic kalula |
Uma kuqhathaniswa nezibophezelo ze-phosphorus zendabuko, i-lanthanum carbonate inezinzuzo ezilandelayo:
Ayikho i-calcium ne-aluminium, ukuphepha okuphezulu: Igwema ingozi ye-hypercalcemia kanye nobuthi be-aluminium, ikakhulukazi ezigulini ezinokwelashwa isikhathi eside kanye nengozi yokubala kwemithambo.
Ikhono eliqinile lokubopha i-phosphorus, umphumela obalulekile wokunciphisa i-phosphorus: I-Lanthanum carbonate ingabopha ngempumelelo i-phosphorus ku-pH ebanzi, futhi ikhono layo lokubopha linamandla kunezibopheli ze-phosphorus zendabuko.
Ukusabela okungekuhle kwesisu okumbalwa, ukuthobela isiguli esihle: I-Lanthanum carbonate inambitheka kahle, kulula ukuyithatha, ayinakucasuka emathunjini, futhi iziguli zisemathubeni amaningi okuthi zibambelele ekwelashweni isikhathi eside.
Ubufakazi bocwaningo lomtholampilo: I-Lanthanum carbonate isebenza kahle
Izifundo eziningi zemitholampilo ziqinisekisile ukusebenza nokuphepha kwe-lanthanum carbonate ezigulini ze-CKD. Ucwaningo luye lwabonisa ukuthi i-lanthanum carbonate ayikho ngaphansi noma iphakeme nakakhulu kunezibophezelo ze-phosphate zendabuko ekunciphiseni amazinga e-phosphorus egazini, futhi ingalawula ngokuphumelelayo amazinga e-iPTH futhi ithuthukise izinkomba ze-bone metabolism. Ukwengeza, ukuphepha kokwelashwa kwesikhathi eside nge-lanthanum carbonate kuhle, futhi akukho ukuqoqwa kwe-lanthanum okusobala kanye nokusabela okunobuthi okutholakele.
Ukwelashwa komuntu ngamunye: Khetha uhlelo olungcono kakhulu lwesiguli
Nakuba i-lanthanum carbonate inezinzuzo eziningi, akusho ukuthi ingabuyisela ngokuphelele izibophezelo ze-phosphate zendabuko. Umuthi ngamunye unezinkomba zawo kanye ne-contraindication, futhi uhlelo lokwelashwa kufanele lube lomuntu ngamunye ngokuya ngesimo esithile sesiguli.
I-Lanthanum carbonate ifaneleka kakhulu ezigulini ezilandelayo:
Iziguli ezine-hypercalcemia noma ingozi ye-hypercalcemia
Iziguli ezine-vascular calcification noma ingozi yokubala kwe-vascular
Iziguli ezinokubekezelelana okungekuhle noma ukungasebenzi kahle kwezibophezelo ze-phosphate zendabuko
Izibophezelo zendabuko ze-phosphate zisengasetshenziselwa iziguli ezilandelayo:
Iziguli ezinezimo zomnotho ezilinganiselwe
Iziguli ezingazwani ne-lanthanum carbonate noma ezingayibekezeleli
Ukubheka esikhathini esizayo: I-Lanthanum carbonate inekusasa eliqhakazile
Ngokujula kocwaningo lomtholampilo kanye nokuqoqwa kokuhlangenwe nakho komtholampilo, isimo se-lanthanum carbonate ekwelapheni i-hyperphosphatemia ezigulini ze-CKD sizoqhubeka nokuba ngcono. Ngokuzayo, i-lanthanum carbonate kulindeleke ukuthi ibe i-phosphate binder yomugqa wokuqala, ilethe izindaba ezinhle ezigulini eziningi ze-CKD.
Isikhathi sokuthumela: Mar-25-2025